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Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer 期刊论文

编号：

06b348f8-22c5-4ce1-8a49-8265d0de872a
作者：

Jiang, Shuheng#^[1,2]Zhu, Lili#^[2]Yang, Jianyu#^[3]Hu, Lipeng^[2];Gu, Jianren^[1,2];Xing, Xin*^[4]Sun, Yongwei*^[3]Zhang, Zhigang*^[2]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2017 年 494 卷 1-2 期 (113 - 119) ; DEC 9
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关键词：

SKCa 4 KCa3.1 SK4 KCNK1 Preneoplastic lesions
摘要：

Dysregulated potassium (K+) channels have previously been shown to promote the development and progression of many types of cancers. Meanwhile, channels are particularly important in regulating the endocrine and exocrine functions of pancreas. However, the expression pattern and prognostic significance of K+ channels in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K+ channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of tissue sections from Pdx1-(C) under bar re; LSL-(K) under bar ras(G12D /+) mice (KC), Pdx1-(C) under bar re; LSL-(K) under bar ras(G12D/+); LSL-Tr (P) under bar 53(R172H/+) mice (KPC) and human PDAC tissue microarrays, we found that Ca2+-activated K+ channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues. Higher epithelial KCNN4 expression was closely correlated with advanced TNM stages and predicted a poor prognosis in patients with PDAC. Elevated KCNN4 expression was significantly associated with shorter survival in univariable and multivariable analyses. Collectively, the identification of expression pattern of K+ channels in PDAC and its precursor PanIN demonstrates the importance of KCNN4 channel during the malignant transformation of PDAC. On the basis of the prognostic signals from two independent cohorts, KCNN4 should be considered as a promising therapeutic target. (C) 2017 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Jiang Shuheng,Zhu Lili,Yang Jianyu, et al. Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,494(1-2):113-119.
APA：

Jiang Shuheng,Zhu Lili,Yang Jianyu,Hu Lipeng,&Zhang Zhigang.(2017).Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,494(1-2):113-119.
MLA：

Jiang Shuheng, et al. "Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 494,1-2(2017):113-119.
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