Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor growth, metastasis, and drug resistance. It is expected that the Hippo pathway will provide novel therapeutic targets for breast cancer. This review will discuss and summarize the roles of several core components of the Hippo pathway in mammary gland development and breast cancer.
[1]Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China.
[2]Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China.
[3]Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
[4]South Med Univ, Affiliated Fengxian Hosp, Dept Lab Med, Shanghai 201499, Peoples R China.
[5]South Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai 201499, Peoples R China.
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