Background Previous studies have shown that exercise could improve beta-cell function in humans or animal models of type 2 diabetes. However, whether it can prevent the progression of pre-diabetes to diabetes remains unclear.
Aim To study the effects of exercise on glycolipid metabolism, beta-cell function, and insulin resistance in the non-diabetic young offsprings of diabetic patients.
Methods One hundred and eighty-two normal glucose tolerance young offsprings of type 2 diabetic parents were enrolled. Individuals with fasting insulin >= 12.0 mU/L were assigned to hyperinsulinemia group (n = 72) and those with fasting insulin <12.0 mU/L were assigned to normal group (n = 110). The subjects in hyperinsulinemia group received 12-week exercise intervention. A 75-g oral glucose tolerance test and insulin release test were conducted before and after intervention. The area under curve of glucose (AUC(glu)), area under curve of insulin (AUC(INS)), HOMA insulin resistance index (HOMA-IR), HOMA beta-cell function (HOMA-beta), and early insulin secretion index (Delta I-30/Delta G(30)) were calculated. Body composition was measured by dual energy X-ray absorptiometry.
Results At baseline, AUCINS and HOMA-beta in hyperinsulinemia group were significantly higher compared with the normal group (P < 0.05). After the 12-week exercise intervention, no significant changes in blood pressure, body mass index, blood glucose, serum lipids, and percentage of body fat were found in hyperinsulinemia group; however, AUCINS, HOMA-beta, HOMA-IR (P < 0.05) and Delta I-30/Delta G(30) (P < 0.01) were significantly decreased.
Conclusions Exercise is effective for preventing prediabetic insulin resistance and b-cell dysfunction in nondiabetic young offsprings of diabetic patients.
[1]Fengxian Cent Hosp, Dept Endocrinol, Shanghai 201400, Peoples R China.
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