Purpose: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting.
Methods: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed.
Results: Twenty-four studies met the inclusion criteria. Incidences of BM based on new diagnosis, length of BM-free interval (BMFI) and number and sites of BM were detected by 17 of 24 studies. Seven studies included in the review were subjected to analyses of risk factors for BM. Developments of SREs regarding the occurrence ratio of total and specific SREs, SERs-free interval (SREFI) and the first-line therapy for SREs were observed in 16 of 24 studies. Out of 5 studies, we extracted uni- and multivariate analysis of risk factor for SREs and out of 16 studies - predictors for survival in breast cancer patients with BM.
Conclusions: BM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors for incidence of BM, SREs and the survival. The unique characteristics of BM and SREs in breast cancer patients should be taken into account in future randomized controlled trials, as to optimize individual treatment options and assure a maximally long good quality of life.
[1]Shanghai Huangpu Dist Cent Hosp, Dept Breast Surg, Shanghai 200002, Peoples R China.
[2]Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China.
[3]Shanghai Univ Med & Hlth Sci, Shanghai 201318, Peoples R China.
[4]Univ Basel, Univ Hosp Basel, Dept Internal Med, Petersgraben 4, CH-4051 Basel, Switzerland.
[5]Shanghai Jiao Tong Univ, Sch Med, Med Sch Lib, Shanghai 200025, Peoples R China.
[6]Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept Psychol Measurement, Shanghai 200030, Peoples R China.
[7]Yankuang Grp Gen Hosp, Dept Pathol, Zoucheng 273500, Shandong Provin, Peoples R China.
(8.0+极速模式)