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Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy

  • 编号:
    29576521-d2ea-4b83-a4bf-6419795b5e53
  • 作者:
    Kuang, Ye(kuangye)#[1] Zhang, KunChi(张坤驰)*[2] Cao, Yi[1] Chen, Xing[3] Wang, Kewei[1] Liu, Min(liumin)*[1] Pei, Renjun(peirenjun)*[1]
  • 地址:

    [1]Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, CAS Key Lab Nanobio Interface, Suzhou 215123, Peoples R China.

    [2]Shanghai Univ Med & Hlth Sci, Shanghai 200120, Peoples R China.

    [3]Guangxi Med Univ, Publ Hlth, Nanning 530021, Peoples R China.

  • 语种:
    英文
  • 期刊:
    ACS APPLIED MATERIALS & INTERFACES ISSN:1944-8244 2017 年 9 卷 14 期 (12217 - 12226) ; 2017
  • 文献号:
    ES2JJ
  • 收录:
  • 关键词:
  • 摘要:

    This is high demand to enhance the accumulation of near-infrared theranostic agents in the tumor region, which is favorable to the effective phototherapy. Compared with indocyanine green (a clinically applied dye), IR-780 iodide possesses higher and more stable fluorescence intensity and can be utilized as an imaging-guided PTT agent with laser irradiation. However, lipophilicity and short circulation time limit its applications in cancer imaging and therapy. Moreover, solid lipid nanoparticles (SLNs) conjugated with c(RGDyK) was designed as efficient carriers to improve the targeted delivery of IR-780 to the tumors. The multifunctional cRGD-IR-780 SLNs exhibited a desirable monodispersity, preferable stability and significant targeting to cell lines overexpressing alpha(v)beta(3) integrin. Additionally, the in vitro assays such as cell viability and in vivo PTT treatment denoted that U87MG cells or U87MG transplantation tumors could be eradicated by applying cRGD-IR-780 SLNs under laser irradiation. Therefore, the resultant cRGD-IR-780 SLNs may serve as a promising NIR imaging-guided targeting PTT agent for cancer therapy.

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  • 基金信息:
    Natural Science Foundation of China [21575154, 21507156]; Natural Science Foundation of Jiangsu Province [BK20161262]; Science and Technology Foundation of Suzhou [SYG201526]; CAS/SAFEA International Innovation Teams program
  • 推荐引用方式
    GB/T 7714:
    Kuang Ye,Zhang Kunchi,Cao Yi, et al. Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy [J].ACS APPLIED MATERIALS & INTERFACES,2017,9(14):12217-12226.
  • APA:
    Kuang Ye,Zhang Kunchi,Cao Yi,Chen Xing,&Pei Renjun.(2017).Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy .ACS APPLIED MATERIALS & INTERFACES,9(14):12217-12226.
  • MLA:
    Kuang Ye, et al. "Hydrophobic IR-780 Dye Encapsulated in cRGD-Conjugated Solid Lipid Nanoparticles for NIR Imaging-Guided Photothermal Therapy" .ACS APPLIED MATERIALS & INTERFACES 9,14(2017):12217-12226.
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