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Prognostic Value of Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) in Patients with Hyperacute Cerebral Infarction Receiving rt-PA Intravenous Thrombolytic Therapy 期刊论文

编号：

45f80b32-778b-4b6b-9f4d-9d69b75b001b
作者：

Sui, HaiJing(隋海晶)#^[1]Yan, ChengGong^[2];Zhao, ZhenGuo(赵振国)*^[1]Bai, QingKe(白青科)^[3]
语种：

英文
期刊：

MEDICAL SCIENCE MONITOR ISSN：1643-3750 2016 年 22 卷 (4438 - 4445) ; NOV 19
收录：
关键词：

Actuarial Analysis Cerebral Infarction Prognosis
摘要：

Background: The aim of this study was to investigate the potential value of apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in the prognosis of patients with hyperacute cerebral infarction (HCI) receiving intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA).
Material/Methods: From June 2012 to June 2015, 58 cases of HCI (<6 h) undergoing rt-PA intravenous thrombolytic therapy (thrombolysis group) and 70 cases of HCI (< 6 h) undergoing conventional antiplatelet and anticoagulant therapy (control group) in the same period were collected. DWI was conducted on all the subjects, and ADC maps were generated with Functool software to quantify ADC value. The clinical outcomes of HCI patients were observed for 3 months, and prognostic factors were analyzed.
Results: Before thrombolysis treatment, the lesion area presented high signal intensity on DWI map and low signal intensity on ADC map, and gradually weakened signal intensity on DWI map and gradually enhanced signal intensity on ADC map were observed after thrombolysis. The ADC values of the thrombolysis group were significantly higher than those of the control group after treatment (24 h, 7 d, 30 d, and 90 d) (all P<0.05), and the ADC and rADC values in the thrombolysis group gradually increased over time (all P<0.05). Multiple logistic regression analysis showed that baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline rADC value, and stroke history were the independent factors for the prognosis of HIC patients with thrombolysis (all P<0.05).
Conclusions: The values of ADC and rADC may provide guidance in the prognosis of HCI patients receiving rt-PA, and the baseline rADC value is the protective factor for the prognosis of HCI patients receiving rt-PA.
推荐引用方式
GB/T 7714：

Sui Hai-Jing,Yan Cheng-Gong,Zhao Zhen-Guo, et al. Prognostic Value of Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) in Patients with Hyperacute Cerebral Infarction Receiving rt-PA Intravenous Thrombolytic Therapy [J].MEDICAL SCIENCE MONITOR,2016,22:4438-4445.
APA：

Sui Hai-Jing,Yan Cheng-Gong,Zhao Zhen-Guo,Bai Qing-Ke.(2016).Prognostic Value of Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) in Patients with Hyperacute Cerebral Infarction Receiving rt-PA Intravenous Thrombolytic Therapy .MEDICAL SCIENCE MONITOR,22:4438-4445.
MLA：

Sui Hai-Jing, et al. "Prognostic Value of Diffusion-Weighted Imaging (DWI) Apparent Diffusion Coefficient (ADC) in Patients with Hyperacute Cerebral Infarction Receiving rt-PA Intravenous Thrombolytic Therapy" .MEDICAL SCIENCE MONITOR 22(2016):4438-4445.
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