Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe3O4@Cu2-xS core-shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core-shell nanoparticles have proven effective as probes for T-2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core-shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications
[1]Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China.
[2]King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Chem & Life Sci & Engn Div, Thuwal 239556900, Saudi Arabia.
[3]Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China.
[4]Chinese Acad Sci, Key Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China.
[5]Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore.
[6]Inst Mat Res & Engn, Singapore 117602, Singapore.
(8.0+极速模式)