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Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2 期刊论文

编号：

4e575f89-dd73-4095-82a4-820995922401
作者：

Zhou, Wenhui#^[1,2,3,4]Fang, Huan#^[1,2,3,5]Wu, Qiuju#^[1,2,3,6]Wang, Xinye^[3];Liu, Rong^[3,7];Li, Fubin^[3];Xiao, Ji^[3];Yuan, Lin^[6];Zhou, Zhongmei^[3];Ma, Junying^[8];Wang, Lulu^[10];Zhao, Weiwei(赵卫卫)^[9]You, Hua^[10];Ju, Jianhua^[8];Feng, Jing*^[1,2,9]Chen, Ceshi*^[3,10,11]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ISSN：1449-2288 2019 年 15 卷 8 期 (1723 - 1732)
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关键词：

Ilamycin E triple-negative breast cancer ER stress CHOP Bcl-2
摘要：

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, in TNBC has not been investigated, and the mechanisms remain elusive. Here, we demonstrated that Ilamycin-E, but not -F, decreases cell viability, inhibits G1/S cell cycle progression, and promotes apoptosis in the TNBC cell lines HCC1937 and MDA-MB-468. Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-induced apoptosis. These findings indicate that Ilamycin E has anti-cancer activity in TNBC.
推荐引用方式
GB/T 7714：

Zhou Wenhui,Fang Huan,Wu Qiuju, et al. Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2 [J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(8):1723-1732.
APA：

Zhou Wenhui,Fang Huan,Wu Qiuju,Wang Xinye,&Chen Ceshi.(2019).Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2 .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(8):1723-1732.
MLA：

Zhou Wenhui, et al. "Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2" .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15,8(2019):1723-1732.
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