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Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model 期刊论文

编号：

5067ec16-7128-4193-b637-9232425e309f
作者：

Yan, Yong#^[1]Zhou, Zhou#^[2]Kong, Fanzhi(孔凡志)^[1]Feng, Suibin^[1]Li, Xuzhong^[1]Sha, Yanhua^[3];Zhang, Guangjun(张光军)^[1]Liu, Haijun(刘海军)^[1]Zhang, Haiqing(张海清)^[1]Wang, Shiguang(王时光)^[1]Hu, Cheng*^[2]Zhang, Xueli(张学利)*^[1]
语种：

英文
期刊：

OBESITY SURGERY ISSN：0960-8923 2016 年 26 卷 11 期 (2683 - 2690) ; NOV
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关键词：

Roux-en-Y gastric bypass Bariatric surgery Type 2 diabetesmellitus Glucose homeostasis Lipid profiles Morphological adaption Gluconeogenesis High-fat diet Streptozotocin
摘要：

Roux-en-Y gastric bypass (RYGB) is an effective surgical treatment for type 2 diabetes mellitus (T2DM). The present study aimed to investigate the effects of RYGB on glucose homeostasis, lipid metabolism, and intestinal morphological adaption, as well as hepatic and intestinal gluconeogenesis.
Twenty adult male T2DM rats induced by high-fat diet and low dose of streptozotocin were randomly divided into sham and RYGB groups. The parameters of body weight, food intake, glucose tolerance, insulin sensitivity, and serum lipid profiles were assessed to evaluate metabolic changes. Intestinal sections were stained with hematoxylin and eosin (H&E) for light microscopy examination. The messenger RNA (mRNA) and protein expression levels of key regulatory enzymes of gluconeogenesis [phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase)] were determined through reverse-transcription PCR (RT-PCR) and Western blotting, respectively.
RYGB induced significant improvements in glucose tolerance and insulin sensitivity, along with weight loss and decreased food intake. RYGB also decreased serum triglyceride (TG) and free fatty acid (FFA) levels. The jejunum and ileum exhibited a marked increase in the length and number of intestinal villi after RYGB. The RYGB group exhibited downregulated mRNA and protein expression levels of PEPCK and G6Pase in the liver and upregulated expression of these enzymes in the jejunum and ileum tissues.
RYGB ameliorates glucose and lipid metabolism accompanied by weight loss and calorie restriction. The small intestine shows hyperplasia and hypertrophy after RYGB. Meanwhile, our study demonstrated that the reduced hepatic gluconeogenesis and increased intestinal gluconeogenesis may contribute to improved glucose homeostasis after RYGB.
推荐引用方式
GB/T 7714：

Yan Yong,Zhou Zhou,Kong Fanzhi, et al. Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model [J].OBESITY SURGERY,2016,26(11):2683-2690.
APA：

Yan Yong,Zhou Zhou,Kong Fanzhi,Feng Suibin,&Zhang Xueli.(2016).Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model .OBESITY SURGERY,26(11):2683-2690.
MLA：

Yan Yong, et al. "Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model" .OBESITY SURGERY 26,11(2016):2683-2690.
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