首页 / 院系成果 / 成果详情页

Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition 期刊论文

编号：

64cc2058-2407-43d7-917d-df67c7bbf660
作者：

Zhu, LinYan#^[1,2,3]Zhang, WenMing#^[4]Yang, XiaoMei^[2];Cui, Lining^[3];Li, Jun^[2];Zhang, YanLi^[2];Wang, YaHui^[2];Ao, JunPing^[2];Ma, MingZe^[2];Lu, Huan^[1]Ren, Yuan^[5];Xu, ShaoHua^[5];Yang, GuangDong^[1]Song, WeiWei^[1]Wang, JingHao^[1]Zhang, XiaoDan^[1]Zhang, Rong*^[1]Zhang, ZhiGang*^[2]
语种：

英文
期刊：

CANCER LETTERS ISSN：0304-3835 2015 年 363 卷 1 期 (71 - 82) ; JUL 10
收录：
关键词：

MICAL-L2 EMT Ovarian cancer Proliferation Invasion
摘要：

Ovarian cancer remains the disease with the highest associated mortality rate of gynecologic malignancy due to cancer metastasis. Rearrangement of actin cytoskeleton by cytoskeleton protein plays a critical role in tumor cell metastasis. MICAL-L2, a member of MICAL family, can interact with actin-binding proteins, regulate actin cross-linking and coordinate the assembly of adherens junctions and tight junctions. However, the roles of MICAL-L2 in tumors and diseases have not been explored. In this study, we found that MICAL-L2 protein is significantly up-regulated in ovarian cancer tissues along with FIGO stage and associated with histologic subgroups of ovarian cancer. Silencing of MICAL-L2 suppressed ovarian cancer cell proliferation, migration and invasion ability. Moreover, silencing of MICAL-L2 prevented nuclear translocation of beta-catenin, inhibited canonical wnt/beta-catenin signaling and induced the mesenchymal-epithelial transition (MET). Taken together, our data indicated that MICAL-L2 may be an important regulator of epithelial-mesenchymal transition (EMT) in ovarian cancer cells and a new therapeutic target for interventions against ovarian cancer invasion and metastasis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Zhu Lin-Yan,Zhang Wen-Ming,Yang Xiao-Mei, et al. Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition [J].CANCER LETTERS,2015,363(1):71-82.
APA：

Zhu Lin-Yan,Zhang Wen-Ming,Yang Xiao-Mei,Cui Lining,&Zhang Zhi-Gang.(2015).Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition .CANCER LETTERS,363(1):71-82.
MLA：

Zhu Lin-Yan, et al. "Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition" .CANCER LETTERS 363,1(2015):71-82.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：35  下载次数：0

分享到：

浏览次数：35

下载次数：0

打印次数：0