Some of the biomedical polymer-drug conjugates are being translated into clinical trials; however, they intrinsically lack photothermal and multi-imaging capabilities, hindering them from imaging-guided precision cancer therapy and complete tumor regression. We introduce a new concept of all-in-one biopolymer-drug conjugate nanotheranostics and prepare a kind of intracellular pH-sensitive polydopamine-doxorubicin (DOX) conjugate nanoparticles (PDCNs) under mild conditions. Significantly, this strategy integrates polymeric prodrug-induced chemotherapy (CT), near-infrared (NIR) light-mediated photothermal therapy (PT), and triple modalities including DOX self-fluorescence, photothermal, and photoacoustic (PA) imaging into one conjugate nanoparticle. The PDCNs present excellent photothermal property, dual stimuli-triggered drug release behavior, and about 12.4-fold blood circulation time compared to free DOX. Small animal fluorescent imaging technique confirms that PDCNs have preferential tumor accumulation effect in vivo, giving a 12.8-fold DOX higher than the control at 12 h postinjection. Upon NIR laser irradiation (5 min, 808 nm, and 2 W.cm(-2)), the PDCN-mediated photothermal effect can quickly elevate the tumor over 50 degrees C, exhibiting good photothermal and PA imaging functions, of which the PA amplitude is 3.6-fold greater than the control. In vitro and in vivo assays persuasively verify that intravenous photothermal-CT of PDCNs produces synergistic antitumor activity compared to single PT or CT, achieving complete tumor ablation during the evaluation period.
[1]Shanghai Jiao Tong Univ, Shanghai Key Lab Elect Insulat & Thermal Aging, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China.
[2]Shanghai Jiao Tong Univ, Joint Res Ctr Precis Med, South Campus, Shanghai 200240, Peoples R China.
[3]Affiliated Sixth Peoples Hosp, South Campus, Shanghai 200240, Peoples R China.
[4]Southern Med Univ, Shanghai Fengxian Hosp, Joint Res Ctr Precis Med, Shanghai 201400, Peoples R China.
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