Background: Although a highly significant association has been described between neutrophil-to-lymphocyte ratio (NLR) and mortality in patients with various types of stroke, the association between NLR and mortality in intracerebral hemorrhage (ICH) patients remains unclear. Methods: In this observational study, we enrolled 224 ICH patients. They were divided into 2 groups based on their 30-day outcomes. Multivariate logistic regression was performed to identify independent risk factors of 30-day mortality. An optimal cutoff value for the continuous NLR was calculated by applying a receiver operating curve analysis to discriminate between the survival and death groups. Results: Among 224 patients, 26 died. No significant difference in NLR at admission was observed between the 2 groups (surviving: 2.39 +/- 1.75 versus nonsurviving: 3.09 +/- 2.16, P = .065), whereas NLR on the next morning following admission was significantly higher in the patients who died (12.53 +/- 9.33) than in those who survived (5.53 +/- 4.68) (P < .001). On multivariate logistic analysis, Glasgow Coma Scale score (odds ratio [OR] .805, 95% confidence interval [CI] .661-.979, P = .030), age (>= 80 years; OR .203, CI .055-.750, P = .017), ICH volume (>= 30 cm(3); OR .112, CI .108-.699, P = .019), and NLR on the next morning (OR 1.091, CI 1.002-1.188, P = .044) were independent risk factors of 30-day mortality. An NLR of 7.35 was identified as the optimal cutoff value. The area under the curve of NLR for 30-day mortality was .762 (P < .001). The mortality was significantly higher in patients with an NLR of 7.35 or higher than in those with an NLR less than 7.35 (31.6% versus 4.8%, P < .001). Conclusions: Higher NLR exhibited an increased mortality in ICH patients. NLR could be used to predict 30-day outcome in ICH patients.
[1]Jiading Dist Ctr Hosp, Emergency Dept, Shanghai 201800, Peoples R China.
[2]Ctr Community Hlth, Shanghai, Peoples R China.
(8.0+极速模式)