Background: Genome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). However, it is not known whether rs10811656 is linked with CAD in a Chinese population. Thus, the purpose of this study was to investigate the potential association between rs10811656 and the risk of CAD in a Chinese population. Methods: We conducted a hospital-based, case-control study with 251 CAD patients and 304 controls to examine the potential association of rs10811656 with CAD. Results: The frequencies of the TT genotypes in CAD cases were significantly different from those in controls (adjusted OR: 1.96, 95 % CI: 1.09-3.505, P = 0.024). Compared to controls, rs10811656 was significantly associated with the stable angina pectoris (adjusted OR: 1.42, 95 % CI: 1.06-1.90, P = 0.017), but not with acute coronary syndrome. There was also a highly significant association of rs10811656 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels (adjusted OR: 1.68 and 1.60, 95 % CI: 1.14-2.44 and 1.10-2.33, P = 0.009 and 0.02, respectively). Conclusion: Our results suggest that the rs10811656 locus might be associated with CAD in a Chinese Han population.
[1]Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China.
[2]Nanjing Med Univ, Affiliated Jiangning Hosp, Devis Cardiol, Nanjing 211100, Jiangsu, Peoples R China.
[3]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Pudong New Area, East Campus,222,Huanhu Xisan Rd, Shanghai 201306, Peoples R China.
(8.0+极速模式)