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Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study 期刊论文

编号：

81293a8b-dc4a-4ed8-8f80-7042bb7f9dd3
作者：

Li, Moyi#^[1,3]Zheng, Guohua(郑国华)*^[2]Zheng, Yuhui^[3];Xiong, Zhenyu^[3];Xia, Rui^[3];Zhou, Wenji^[3];Wang, Qin^[4];Liang, Shengxiang^[5,6,7];Tao, Jing^[3];Chen, Lidian#*^[3,8]
语种：

英文
期刊：

BMC MEDICAL IMAGING ISSN：1471-2342 2017 年 17 卷 ; AUG 16
收录：
关键词：

Amnestic mild cognitive impairment Default mode network Functional magnetic resonance imaging Functional connectivity Independent component analysis
摘要：

Background: Amnestic mild cognitive impairment (aMCI) is characterized by cognitive functional decline, especially in memory. Resting-state functional magnetic resonance imaging (fMRI) has been widely used in neuroimaging studies that explore alterations between patients and normal individuals to elucidate the pathological mechanisms of different diseases. The current study was performed to investigate alterations in the functional connectivity of the default mode network (DMN) in aMCI patients compared to healthy elderly controls, as well as further define the association between neurological alterations and memory function.
Methods: Twenty-five aMCI patients and 25 healthy individuals were recruited and underwent both fMRI and neuropsychological examinations. fMRI data was analyzed by independent component analysis.
Results: Compared to healthy individuals, aMCI patients exhibited a significant increase in functional connectivity between the DMN and right-middle and right-superior frontal gyri, left-middle occipital gyrus, and left-middle temporal gyrus, but reduced functional connectivity between the DMN and left-middle and left-inferior frontal gyri and left insula. These alterations were found to be associated with reduced memory function.
Conclusions: aMCI patients exhibited abnormal functional connectivity between the DMN and certain brain regions which is associated with changes in memory function associated with aMCI.
推荐引用方式
GB/T 7714：

Li Moyi,Zheng Guohua,Zheng Yuhui, et al. Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study [J].BMC MEDICAL IMAGING,2017,17.
APA：

Li Moyi,Zheng Guohua,Zheng Yuhui,Xiong Zhenyu,&Chen Lidian.(2017).Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study .BMC MEDICAL IMAGING,17.
MLA：

Li Moyi, et al. "Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study" .BMC MEDICAL IMAGING 17(2017).
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