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A spiropyran-based fluorescent probe for the specific detection of beta-amyloid peptide oligomers in Alzheimer's disease

  • 作者:
    Lv, Guanglei(lvguanglei)#[1,2] Sun, AnYang(孙安阳)*[3] Wei, Peng[1,2] Zhang, Ning[3] Lan, Haichuang[1,2] Yi, Tao[1,2]
  • 地址:

    [1]Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China;

    [2]Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Shanghai 200433, Peoples R China;

    [3]Shanghai Univ Med & Hlth Sci, Lab Neurodegenerat Dis & Mol Imaging, Shanghai 201318, Peoples R China

  • 语种:
    英文
  • 期刊:
    CHEMICAL COMMUNICATIONS ISSN:1359-7345 2016 年 52 卷 57 期 (8865 - 8868)
  • 收录:
  • 摘要:

    We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Ab oligomers both in vitro and in vivo. This probe can penetrate the blood brain barrier and specifically target Ab oligomers in the brains of transgenic mice in models for Alzheimer's disease.

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  • 基金信息:
    NNSFC [21125104, 51373039]; [2013CB733700]
  • 推荐引用方式
    GB/T 7714:
    Lv Guanglei,Sun Anyang,Wei Peng, et al. A spiropyran-based fluorescent probe for the specific detection of beta-amyloid peptide oligomers in Alzheimer's disease [J].CHEMICAL COMMUNICATIONS,2016,52(57):8865-8868.
  • APA:
    Lv Guanglei,Sun Anyang,Wei Peng,Zhang Ning,&Yi Tao.(2016).A spiropyran-based fluorescent probe for the specific detection of beta-amyloid peptide oligomers in Alzheimer's disease .CHEMICAL COMMUNICATIONS,52(57):8865-8868.
  • MLA:
    Lv Guanglei, et al. "A spiropyran-based fluorescent probe for the specific detection of beta-amyloid peptide oligomers in Alzheimer's disease" .CHEMICAL COMMUNICATIONS 52,57(2016):8865-8868.
  • 条目包含文件:
    文件类型:.pdf,文件大小:2.89 M
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