Background: The current study aimed to investigate low cerebral perfusion, white matter hyperintensity, and cognitive dysfunction in stroke-free patients with moderate-to-severe intracranial arterial stenosis. Materials and methods: Patients with hypomnesis were recruited. Vascular risk factors were recorded. Intracranial artery stenosis, stenosis load, blood flow perfusion values, white matter hyperintensity, and cognition were assessed. Results: Patients with arterial stenosis were older and had a higher incidence of hypertension. Patients with arterial stenosis had a significantly higher incidence of cognitive dysfunction, compared with the control group (P < 0.05). Correlation analysis showed that intracranial arterial stenosis load was significantly negatively related to total MoCA scores (P < 0.001). Cerebral perfusion at the periventricular area in the stenosis group was significantly lower than that in the control group (P < 0.01). Arterial stenosis load was negative to blood flow (P < 0.05). Incidence of white matter hyperintensity in the frontal lobe, temporal lobe, occipital lobe, and antecornu and peri-ventricular areas in the stenosis group was significantly higher than that in the control group. Arterial stenosis load was positively related to whole-brain white matter hyperintensity (P < 0.05). Conclusion: Intracranial arterial stenosis load is negatively related to total MoCA scores and ventricular area blood flow perfusion, but positively associated with whole-brain white matter hyperintensity.
[1]Tongji Univ, Shanghai Tongji Hosp, Sch Med, Dept Neurol, 389 Xincun Rd, Shanghai 200065, Peoples R China.
[2]Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai 201318, Peoples R China.
[3]Tongji Univ, Dept Psychiat, Tongji Hosp, Sch Med,Shanghai Tongji Hosp, Shanghai 200065, Peoples R China.
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