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Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway 期刊论文

编号：

F8B52E67A6F7FC2261BDF4A22C0F28A1
作者：

Ni, XianQiang#^[1,2,3]Zhang, YaRong#^[1,2,3]Jia, LiXin^[4];Lu, WeiWei^[1,2,3];Zhu, Qing^[1,2,3];Ren, JinLing^[1,2,3];Chen, Yao^[1,2,3];Zhang, LinShuang^[1,2,3];Liu, Xin^[1,2,3];Yu, YanRong^[3];Jia, MoZhi^[3];Ning, ZhongPing^[5];Du, Jie^[4];Tang, ChaoShu^[2,3];Qi, YongFen*^[1,2,3]
语种：

英文
期刊：

AGING-US ISSN：1945-4589 2021 年 13 卷 4 期 (5164 - 5184) ; FEB 28
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关键词：

abdominal aortic aneurysm intermedin Notch1 IMD transgenic and knockout mice ADAM10
摘要：

The Notch1-mediated inflammatory response participates in the development of abdominal aortic aneurysm (AAA). The vascular endogenous bioactive peptide intermedin (IMD) plays an important role in maintaining vascular homeostasis. However, whether IMD inhibits AAA by inhibiting Notch1-mediated inflammation is unclear. In this study, we found Notch intracellular domain (NICD) and hes1 expression were higher in AAA patients' aortas than in healthy controls. In angiotensin II (AngII)-induced AAA mouse model, IMD treatment significantly reduced AAA incidence and maximal aortic diameter. IMD inhibited AngII-enlarged aortas and-degraded elastic lamina, reduced NICD, hes1 and inflammatory factors expression, decreased infiltration of CD68 positive macrophages and the NOD-like receptor family pyrin domain containing 3 protein level. IMD inhibited lipopolysaccharide-induced macrophage migration in vitro and regulated macrophage polarization. Moreover, IMD overexpression significantly reduced CaCl2-induced AAA incidence and down-regulated NICD and hes1 expression. However, IMD deficiency showed opposite results. Mechanically, IMD treatment significantly decreased cleavage enzyme-a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) level. Pre-incubation with IMD17-47 (IMD receptors blocking peptide) and the phosphatidylinositol 3-kinase/protein kinase b (PI3K/Akt) inhibitor LY294002 reversed ADAM10 level. In conclusion, exogenous and endogenous IMD could inhibit the development of AAA by inhibiting Notch1 signaling-mediated inflammation via reducing ADAM10 through IMD receptor and PI3K/Akt pathway.
推荐引用方式
GB/T 7714：

Ni Xian-Qiang,Zhang Ya-Rong,Jia Li-Xin, et al. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway [J].AGING-US,2021,13(4):5164-5184.
APA：

Ni Xian-Qiang,Zhang Ya-Rong,Jia Li-Xin,Lu Wei-Wei,&Qi Yong-Fen.(2021).Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway .AGING-US,13(4):5164-5184.
MLA：

Ni Xian-Qiang, et al. "Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway" .AGING-US 13,4(2021):5164-5184.
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