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Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer 期刊论文

编号：

c43bd5ba-80ce-4333-9523-91bc2349b2fe
作者：

Meng, Zhenzhen#^[1]Liu, Ying(刘盈)^[2]Wang, Jie^[3,4,5]Fan, Hongjia^[3,4,5]Fang, Huan^[2]Li, Sha^[2]Yuan, Lin^[4,5]Liu, Cuicui(刘萃萃)^[4,5]Peng, You(彭攸)^[4,5]Zhao, Weiwei(赵卫卫)^[4,5]Wang, Lulu^[4,5]Li, Jing*^[4,5,6,7]Feng, Jing(冯景)*^{[1,4,5,6,7,8]}
语种：

英文
期刊：

JOURNAL OF CELLULAR PHYSIOLOGY ISSN：0021-9541 2020 年 235 卷 2 期 (932 - 943) ; FEB
收录：
关键词：

apoptosis breast cancer stem cell KDM7A stem cell maintenance
摘要：

Histone demethylase KDM7A regulates neuronal differentiation and development in mammals. In this study, we found that KDM7A was also required for breast cancer stem cells (BCSCs) maintenance. Silencing KDM7A significantly reduced the BCSCs population and mamosphere formation in vitro, and inhibited breast tumor growth in vivo. Restoring KDM7A expression rescued the defect in stem cell maintenance. Our mechanism analysis suggested that KDM7A upregulated the stemness-associated factors KLF4 and c-MYC for BCSCs maintenance. In addition, KDM7A knockdown promoted apoptosis through decreasing BCL2 expression and BAD phosphorylation in breast cancer (BrCa). Furthermore, restoring KDM7A and BCL2 expression rescued apoptosis inhibition in breast cancer, suggesting that KDM7A inhibited apoptosis by upregulating the BCL2 level in breast cancer. In conclusion, KDM7A promotes cancer stem cell maintenance and apoptosis inhibition in breast cancer.
推荐引用方式
GB/T 7714：

Meng Zhenzhen,Liu Ying,Wang Jie, et al. Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer [J].JOURNAL OF CELLULAR PHYSIOLOGY,2020,235(2):932-943.
APA：

Meng Zhenzhen,Liu Ying,Wang Jie,Fan Hongjia,&Feng Jing.(2020).Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer .JOURNAL OF CELLULAR PHYSIOLOGY,235(2):932-943.
MLA：

Meng Zhenzhen, et al. "Histone demethylase KDM7A is required for stem cell maintenance and apoptosis inhibition in breast cancer" .JOURNAL OF CELLULAR PHYSIOLOGY 235,2(2020):932-943.
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