National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81872418]; Shanghai Natural Science FoundationNatural Science Foundation of Shanghai [18ZR1431700]; Shanghai Municipal Health and Family Planning Commission Project [201540027, 20174Y0236, 20184Y0104]; Seed Fund Program of Shanghai University of Medicine & Health Sciences [HSMF-17-22-031, SFP-18-21-15-003, SPF-18-20-15-001]; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai [2017YQ048]; Shanghai Fengxian District Science and Technology Project [20181601]