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Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus 期刊论文

编号：

d7fee970-93fd-4358-abc6-e30557b088a0
作者：

Luo, Fang#^[1,2]Mu, Yuling#^[1,2]Gao, Cuicui#^[1,2,3,4]Xiao, Yan^[5,6];Zhou, Qian^[1,2,3,4];Yang, Yiqing^[1,2];Ni, Xinyan^[1,2];Shen, Wei L.*^[1,2]Yang, Jiajun(杨嘉君)*^[5,6]
语种：

英文
期刊：

JOURNAL OF GENETICS AND GENOMICS ISSN：1673-8527 2019 年 46 卷 1 期 (31 - 40) ; JAN 20
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关键词：

BDNF Transsynaptic tracing Obesity Feeding Thermogenesis
摘要：

Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis. Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. Copyright (C) 2019, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
推荐引用方式
GB/T 7714：

Luo Fang,Mu Yuling,Gao Cuicui, et al. Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus [J].JOURNAL OF GENETICS AND GENOMICS,2019,46(1):31-40.
APA：

Luo Fang,Mu Yuling,Gao Cuicui,Xiao Yan,&Yang Jiajun.(2019).Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus .JOURNAL OF GENETICS AND GENOMICS,46(1):31-40.
MLA：

Luo Fang, et al. "Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus" .JOURNAL OF GENETICS AND GENOMICS 46,1(2019):31-40.
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