Zeolitic imidazolate framework-8 (ZIF-8), one kind of metal-organic frameworks, has attracted much attention in biomedicine applications. In this manuscript, a novel gold nanorods@ zeolitic imidazolate framework-8 (Au NR@ZIF-8) core-shell nanostructure has been successfully prepared via a facile step-bystep route. The phase, structure, morphology, and surface properties of the obtained core-shell nanostructure were characterized by XRD, SEM, TEM, Zeta, and FTIR analysis. The core-shell nanostructure showed good photothermal performances and photoacoustic (PA) imaging capability resulting from Au NR. The coated metal-organic framework ZIF-8 shell made the nanostructure easily to be modified for further bioapplications. The MTT assay demonstrated that the nanostructure possessed low cell cytotoxicity and had potential biomedical applications. (C) 2018 Elsevier B.V. All rights reserved.
[1]Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Med Engn, Xian 710061, Shaanxi, Peoples R China.
[2]Shanghai Univ Med & Hlth Sci, Inst Nanotechnol & Hlth Sci, Shanghai 201308, Peoples R China.
[3]Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China.
[4]Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China.
[5]Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China.
[6]MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.
(8.0+极速模式)