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Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats 期刊论文

编号：

f0ec3fd7-bb61-4dc7-a06a-731387407590
作者：

Zhang, Xueli(张学利)#*^[1]Huang, Wenhai#^[2]Zhang, Yong^[2];Zhou, Wenhua(周文华)^[1]Zhou, Lianming(周联明)^[1]Huang, Zhongming(黄忠明)^[1]Qu, Jun(瞿军)^[1]Gao, Ganglong(高钢龙)^[1]Huo, Shoujun^[1]Kong, Fanzhi(孔凡志)^[1]Zhang, JiFa(张吉发)*^[1]
语种：

英文
期刊：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES ISSN：0930-2794 2011 年 25 卷 11 期 (3493 - 3498) ; NOV
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关键词：

Gastric bypass surgery Operative styles Type 2 diabetes Effect
摘要：

Aim To investigate the therapeutic effects of different styles of gastric bypass surgery on type 2 diabetes mellitus (T2DM) GK rats.
Methods Twenty 6-8-week-old male GK rats were randomly divided into four groups: group A was operated by Roux-en-Y gastrojejunostomy with duodenum exclusion and stomach capacity maintenance, group B was operated by loop-type gastrojejunostomy with duodenum exclusion and stomach capacity maintenance, group C was operated by Roux-en-Y gastrojejunostomy with partial gastrectomy, and group D was operated by loop-type gastrojejunostomy with partial gastrectomy. Changes of fasting blood glucose, oral glucose tolerance test (OGTT), and insulin tolerance test (ITT) in different operations were detected.
Results The operations exerted good effects on controlling blood glucose in groups A, B, C, and D. There was no significant difference between groups A and C (P > 0.05) or between groups B and D (P > 0.05), while operations in groups A and C were more effective than groups B and D (P < 0.05). On the 21st day after surgery, OGTT in animals of groups A and C was significantly improved, as indicated by a 34% reduction in the area under the curve (AUC) for blood glucose (P < 0.05 versus groups B and D); pregavage insulin levels (ng/ml) were significantly decreased in groups A and C (P < 0.05 versus groups B and D). The insulin tolerance test (ITT) confirmed impaired insulin sensitivity in groups B and D, compared with groups A and C.
Conclusions Gastric bypass surgery might be effective to treat type 2 diabetes mellitus (T2DM), and Roux-en-Y gastrojejunostomy might be more effective than other operative styles.
推荐引用方式
GB/T 7714：

Zhang Xueli,Huang Wenhai,Zhang Yong, et al. Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats [J].SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,2011,25(11):3493-3498.
APA：

Zhang Xueli,Huang Wenhai,Zhang Yong,Zhou Wenhua,&Zhang Ji-Fa.(2011).Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats .SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,25(11):3493-3498.
MLA：

Zhang Xueli, et al. "Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats" .SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 25,11(2011):3493-3498.
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