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miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke 期刊论文

编号：

f2111e9e-9459-4927-9c53-1b51efac5160
作者：

Zhang, Rong#^[1,3,4]Zhou, Weipin#^[1]Yu, Zhijun#^[1]Yang, Ling^[1];Liu, Guangqi^[1];Yu, Haotian^[1];Zhou, Qianyi^[1];Min, Zhenli^[1];Zhang, Chunxiang^[1,3,4,5];Wu, Qingming^[1];Hu, XiaMin*^[2]Yuan, Qiong*^[1,3,4,5]
语种：

英文
期刊：

BRAIN RESEARCH ISSN：0006-8993 2019 年 1714 卷 (18 - 26) ; JUL 1
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关键词：

miR-1247-3p Caspase-2 Apoptosis Myocardin-related transcription factor-A Ischemia/reperfusion Stroke
摘要：

Brain stroke is one of the leading causes of death worldwide. We explored a potential stroke-related role for a newly found microRNA, miR-1247-3p, and one of its target genes, caspase-2, predicted by TargetScanVert. In the present study, we found that miR-1247-3p was downregulated during ischemia/reperfusion (I/R) and that LV-miR-1247-3p overexpression attenuated brain impairment induced by I/R. Similar results were observed in neuro2a (N2a) cells treated with oxygen -glucose deprivation/reoxygenation (OGD/R). Caspase-2 was upregulated in the I/R and OGD/R model, while Z-VDVAD-FMK the inhibitor of caspase-2-inhibited apoptosis of N2a cells induced by OGD/R. An miR-1247-3p mimic inhibited caspase-2 expression and attenuated apoptosis of N2a cells induced by OGD/R. Myocardin-related transcription factor-A (MRTF-A) overexpression upregulated miR-1247 and mature miR-1247-3p levels and attenuated apoptosis induced by OGD/R, whereas its anti-apoptotic function could be blocked by a miR-1247-3p inhibitor. Hence, we conclude that miR-1247-3p may protect cells during brain stroke. This study offers insights for the development of effective therapeutics for promoting the survival of cerebral neurons during brain I/R injury.
推荐引用方式
GB/T 7714：

Zhang Rong,Zhou Weipin,Yu Zhijun, et al. miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke [J].BRAIN RESEARCH,2019,1714:18-26.
APA：

Zhang Rong,Zhou Weipin,Yu Zhijun,Yang Ling,&Yuan Qiong.(2019).miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke .BRAIN RESEARCH,1714:18-26.
MLA：

Zhang Rong, et al. "miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke" .BRAIN RESEARCH 1714(2019):18-26.
入库时间：

10/23/2019 2:37:49 PM
更新时间：

10/23/2019 2:37:49 PM
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