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Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers 期刊论文

编号：

f5bdbfa1-5a91-4969-973c-016ce86f3cbb
作者：

Liu, YeWei#^[1,2,3,4,5]De Keyzer, Frederik^[2];Feng, YuanBo^[2];Chen, Feng^[2];Song, ShaoLi^[3];Swinnen, Johan^[2];Bormans, Guy^[2];Oyen, Raymond^[2];Huang, Gang(黄钢)^[1,3,4,5]Ni, YiCheng*^[2]
语种：

英文
期刊：

WORLD JOURNAL OF GASTROENTEROLOGY ISSN：1007-9327 2018 年 24 卷 25 期 (2710 - 2721) ; JUL 7
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关键词：

Hepatocellular carcinoma Combretastatin A4 phosphate Rhabdomyosarcoma Vascular-disrupting agent Magnetic resonance imaging Rats
摘要：

AIM
To compare therapeutic responses of a vascular disrupting-agent, combretastatin-A4-phosphate (CA4P), among hepatocellular carcinomas (HCCs) and implanted rhabdomyosarcoma (R1) in the same rats by magneticresonance-imaging (MRI), microangiography and histopathology.
METHODS
Thirty-six HCCs were created by diethylnitrosamine gavage in 14 rats that were also intrahepatically implanted with one R1 per rat as monitored by T2-/T1-weighted images (T2WI/T1WI) on a 3.0T clinical MRI-scanner. Vascular response and tumoral necrosis were detected by dynamic contrast-enhanced (DCE-) and CE-MRI before, 1 h after and 12 h after CA4P iv at 10 mg/kg (treatment group n = 7) or phosphate-buffered saline at 1.0 mL/kg (control group n = 7). Tumor blood supply was calculated by a semiquantitative DCE parameter of area under the time signal intensity curve (AUC30). In vivo MRI findings were verified by postmortem techniques.
RESULTS
On CE-T1WIs, unlike the negative response in all tumors of control animals, in treatment group CA4P caused rapid extensive vascular shutdown in all R1-tumors, but mildly or spottily in HCCs at 1 h. Consequently, tumor necrosis occurred massively in R1-tumors but patchily in HCCs at 12 h. AUC30 revealed vascular closure (66%) in R1-tumors at 1 h (P < 0.05), followed by further perfusion decrease at 12 h (P < 0.01), while less significant vascular clogging occurred in HCCs. Histomorphologically, CA4P induced more extensive necrosis in R1-tumors (92.6%) than in HCCs (50.2%) (P < 0.01); tumor vascularity heterogeneously scored +similar to+++ in HCCs but homogeneously scored ++ in R1-tumors.
CONCLUSION
This study suggests superior performance of CA4P in metastatic over primary liver cancers, which could guide future clinical applications of vascular-disrupting-agents.
推荐引用方式
GB/T 7714：

Liu Ye-Wei,De Keyzer Frederik,Feng Yuan-Bo, et al. Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers [J].WORLD JOURNAL OF GASTROENTEROLOGY,2018,24(25):2710-2721.
APA：

Liu Ye-Wei,De Keyzer Frederik,Feng Yuan-Bo,Chen Feng,&Ni Yi-Cheng.(2018).Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers .WORLD JOURNAL OF GASTROENTEROLOGY,24(25):2710-2721.
MLA：

Liu Ye-Wei, et al. "Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers" .WORLD JOURNAL OF GASTROENTEROLOGY 24,25(2018):2710-2721.
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