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ImmunoPET: Concept, Design, and Applications 期刊论文 WOS高被引论文

编号：

4C345B4EA146B4480220CAD62BDC6096
作者：

Wei, Weijun(魏伟军)#^[1,2,6]Rosenkrans, Zachary T.^[3]Liu, Jianjun(刘建军)^[6]Huang, Gang(黄钢)*^[6,7]Luo, QuanYong(罗全勇)*^[5]Cai, Weibo(蔡伟波)*^[1,2,3,4]
语种：

英文
期刊：

CHEMICAL REVIEWS ISSN：0009-2665 2020 年 120 卷 8 期 (3787 - 3851) ; APR 22
收录：
摘要：

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) and the inherent sensitivity of PET technique. A variety of radionuclides and mAbs have been exploited to develop immunoPET probes, which has been driven by the development and optimization of radiochemistry and conjugation strategies. In addition, tumor-targeting vectors with a short circulation time (e.g., Nanobody) or with an enhanced binding affinity (e.g., bispecific antibody) are being used to design novel immunoPET probes. Accordingly, several immunoPET probes, such as Zr-89-Df-pertuzumab and Zr-89-atezolizumab, have been successfully translated for clinical use. By noninvasively and dynamically revealing the expression of heterogeneous tumor antigens, immunoPET imaging is gradually changing the theranostic landscape of several types of malignancies. ImmunoPET is the method of choice for imaging specific tumor markers, immune cells, immune checkpoints, and inflammatory processes. Furthermore, the integration of immunoPET imaging in antibody drug development is of substantial significance because it provides pivotal information regarding antibody targeting abilities and distribution profiles. Herein, we present the latest immunoPET imaging strategies and their preclinical and clinical applications. We also emphasize current conjugation strategies that can be leveraged to develop next-generation immunoPET probes. Lastly, we discuss practical considerations to tune the development and translation of immunoPET imaging strategies.
推荐引用方式
GB/T 7714：

Wei Weijun,Rosenkrans Zachary T.,Liu Jianjun, et al. ImmunoPET: Concept, Design, and Applications [J].CHEMICAL REVIEWS,2020,120(8):3787-3851.
APA：

Wei Weijun,Rosenkrans Zachary T.,Liu Jianjun,Huang Gang,&Cai Weibo.(2020).ImmunoPET: Concept, Design, and Applications .CHEMICAL REVIEWS,120(8):3787-3851.
MLA：

Wei Weijun, et al. "ImmunoPET: Concept, Design, and Applications" .CHEMICAL REVIEWS 120,8(2020):3787-3851.
入库时间：

9/27/2020 12:36:04 PM
更新时间：

9/27/2020 12:36:04 PM

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