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Rapid detection of des-gamma-carboxy prothrombin with disposable screen printed ITO electrode based on multiple signal amplification strategy of metal-organic skeleton material 期刊论文

编号：

BE2B7E8FCFD1B3C23AFC96F03673016D
作者：

Chang, Dong#^[1]Wang, Zhangmin^[2];Xu, Xin^[1];Shen, Tong^[1];Yu, Hongwei^[1];Zhang, Yuting^[1];An, Xiaohui^[1];Fan, Yiyang^[1];Yang, Xiaoyi^[1];Pan, Hongzhi(潘洪志)*^[3]Zhang, Ze*^[1]
语种：

英文
期刊：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY ISSN：1572-6657 2025 年 977 卷 ; JAN 15
收录：
关键词：

Immunosensor Des-gamma-carboxy prothrombin IROMF-3 Electrochemical
摘要：

A multi-signal amplification system using an ITO electrode printed with disposable screen ink was developed for the rapid detecting des-gamma-carboxy prothrombin (DCP). Gold nanoparticles, uniformly shaped, were electrodeposited on the ITO electrode to improve conductivity and biocompatibility. To boost the sensor''s sensitivity, isoreticular metal-organic framework-3 (IROMF-3) and methylene blue (MB) were employed to expand the electrode''s surface area and intensify the current signal. Additionally, the avidin-loaded silver nanoelectrode, capable of binding more biotinylated DCP antibodies, further heightened sensitivity. The developed immunosensor effectively detected trace DCP in serum, with a linear range of 0.31 ng/mL to 40 ng/mL, a detection limit of 0.138 ng/mL, and a recovery rate of 97.9-109.2 % under optimal experimental conditions. This study offers a promising approach for the rapid field detection of trace DCP in serum.
推荐引用方式
GB/T 7714：

Chang Dong,Wang Zhangmin,Xu Xin, et al. Rapid detection of des-gamma-carboxy prothrombin with disposable screen printed ITO electrode based on multiple signal amplification strategy of metal-organic skeleton material [J].JOURNAL OF ELECTROANALYTICAL CHEMISTRY,2025,977.
APA：

Chang Dong,Wang Zhangmin,Xu Xin,Shen Tong,&Zhang Ze.(2025).Rapid detection of des-gamma-carboxy prothrombin with disposable screen printed ITO electrode based on multiple signal amplification strategy of metal-organic skeleton material .JOURNAL OF ELECTROANALYTICAL CHEMISTRY,977.
MLA：

Chang Dong, et al. "Rapid detection of des-gamma-carboxy prothrombin with disposable screen printed ITO electrode based on multiple signal amplification strategy of metal-organic skeleton material" .JOURNAL OF ELECTROANALYTICAL CHEMISTRY 977(2025).
入库时间：

1/14/2025 9:23:27 PM
更新时间：

1/14/2025 9:23:27 PM

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