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Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative 期刊论文

编号：

C0A6BF2B91EC85260B6A3CA8A23C54BA
作者：

Jiang, Guowei(姜国伟)#^[1]Chang, Qing(常庆)#^[2]Liang, Dongyu(梁冬雨)^[2]Zhang, Yuting^[3]Meng, Yongjun(孟拥军)^[1]Yi, Qingqing(易清清)*^[2]
语种：

英文
期刊：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH ISSN：0300-0605 2020 年 48 卷 2 期 ; FEB
收录：
关键词：

Nucleophilic substitution reduction ammonification reaction 4-amino-1 2 4-triazole Schiff base derivative product characterization anticancer MTT assay
摘要：

Objectives
The purpose of this paper was to synthesize 4-amino-1,2,4-triazole Schiff base derivative and to evaluate its antitumor activity.
Methods
2,4,6-Tris (4-formylphenoxy)-1,3,5-triazine was synthesized by nucleophilic substitution with reaction of p-hydroxybenzaldehyde with cyanuric chloride. Then, the intermediate was reacted with 1,2,4-triazole to form 4-amino-1,2,4-triazole Schiff base derivative by reduction and ammonification of aldehydes. The 4-amino-1,2,4-triazole Schiff base derivative was characterized by infrared spectroscopy, nuclear magnetic resonance, and elemental analyses. Finally, the anticancer effect of 4-amino-1,2,4-triazole Schiff base derivative was evaluated by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay on a lung adenocarcinoma cell line (A549) and a human hepatoma cell line (Bel7402).
Results
The product synthesized in this study was confirmed to be 4-amino-1,2,4-triazole Schiff base derivative, and it significantly suppressed the proliferation of cancer cell lines in a dose-dependent manner.
Conclusions
We successfully prepared 4-amino-1,2,4-triazole Schiff base derivative and verified its antitumor activity.
推荐引用方式
GB/T 7714：

Jiang Guo-wei,Chang Qing,Liang Dong-yu, et al. Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative [J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2020,48(2).
APA：

Jiang Guo-wei,Chang Qing,Liang Dong-yu,Zhang Yu-ting,&Yi Qing-qing.(2020).Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative .JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48(2).
MLA：

Jiang Guo-wei, et al. "Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative" .JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48,2(2020).
入库时间：

3/7/2020 8:14:28 PM
更新时间：

3/7/2020 8:14:28 PM
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