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Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation 期刊论文

编号：

C7D00C752032631646B13AFA739335AB
作者：

Zhang, Yongsheng#^[1,2]Wang, Jincheng^[1,3];Yang, Zhenjiao^[1,2];Zhang, Zeng^[1,3];He, Xiaoyan(何小燕)^[1]Chen, Guoliang(陈国良)*^[2]Huang, Gang(黄钢)*^[1]Lu, Xiuhong(陆秀宏)*^[1,3]
语种：

英文
期刊：

JOURNAL OF ORGANIC CHEMISTRY ISSN：0022-3263 2021 年 86 卷 24 期 (17696 - 17709) ; DEC 17
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摘要：

Diimine (HN=NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine-copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broadfunctional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkalies directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the mechanism. Alzheimer''s disease drug CT-1812 and studied the mechanism.
推荐引用方式
GB/T 7714：

Zhang Yongsheng,Wang Jincheng,Yang Zhenjiao, et al. Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation [J].JOURNAL OF ORGANIC CHEMISTRY,2021,86(24):17696-17709.
APA：

Zhang Yongsheng,Wang Jincheng,Yang Zhenjiao,Zhang Zeng,&Lu Xiuhong.(2021).Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation .JOURNAL OF ORGANIC CHEMISTRY,86(24):17696-17709.
MLA：

Zhang Yongsheng, et al. "Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation" .JOURNAL OF ORGANIC CHEMISTRY 86,24(2021):17696-17709.
入库时间：

3/15/2022 2:08:29 PM
更新时间：

3/15/2022 2:08:29 PM
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