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The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study 期刊论文

编号：

CBF4BD9A891B90519D55DBFB4C663F42
作者：

Jiang, Liying(姜丽英)#^[1,2]Jiang, Ying#^[3]Wang, Anqi^[4];Wu, Cui*^[5]Shen, Yi*^[6]
语种：

英文
期刊：

FRONTIERS IN ENDOCRINOLOGY ISSN：1664-2392 2023 年 13 卷 ; JAN 11
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关键词：

osteoarthritis bone mineral density single nucleotide polymorphisms Mendelian randomization genome-wide association studies
摘要：

ObjectivesThe causal direction and magnitude of the association between total body bone mineral density (TB-BMD) and osteoarthritis (OA) risk is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. The study aimed to explore the relationships between TB-BMD concentration and OA using Mendelian randomization (MR). MethodsIn this study, we used two-sample MR to obtain unconfounded estimates of the effect of TB-BMD on hip and knee OA. Single nucleotide polymorphisms (SNPs) strongly associated with TB-BMD in a large genome-wide association study (GWAS) were identified and selected as instrumental variables (IVs). In addition to the main analysis using inverse-variance weighted (IVW) method, we applied 2 additional methods to control for pleiotropy(MR-Egger regression, weighted median estimator) and compared the respective MR estimates. ResultsMR analyses suggested that genetically predicted higher TB-BMD is associated with risks of hip OA (For IVW: OR=1.199, 95%CI: 1.02-1.42, P=0.032; for WM: OR=1.257, 95%CI: 1.09-1.45, P=0.002). There was no evidence that the observed causal effect between TB-BMD and the risk of hip OA was affected by genetic pleiotropy(P=0.618). Additionally, our study didn''t support causal effects of a genetically increased TB-BMD risk on knee OA risk(OR=1.121, 95%CI: 0.99-1.28, P=0.084 using IVW; OR=1.132, 95%CI: 0.99-1.29, P=0.068 using WM; OR=1.274, 95%CI: 0.88-1.85, P=0.217 using MR-Egger). ConclusionsOur findings support a causal effect that a genetic predisposition to systematically higher TB-BMD was associated with the risk of OA. And, TB-BMD likely exerts an effect on the risk of hip OA not knee OA.
推荐引用方式
GB/T 7714：

Jiang Liying,Jiang Ying,Wang Anqi, et al. The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study [J].FRONTIERS IN ENDOCRINOLOGY,2023,13.
APA：

Jiang Liying,Jiang Ying,Wang Anqi,Wu Cui,&Shen Yi.(2023).The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study .FRONTIERS IN ENDOCRINOLOGY,13.
MLA：

Jiang Liying, et al. "The causal association between bone mineral density and risk of osteoarthritis: A Mendelian randomization study" .FRONTIERS IN ENDOCRINOLOGY 13(2023).
入库时间：

2/18/2023 10:13:29 PM
更新时间：

2/18/2023 10:13:29 PM
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