首页 / 院系成果 / 成果详情页

SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription  期刊论文  

  • 编号:
    DEC4C1A901AD5ACD05ECAE1191A3B818
  • 作者:
    Chen, Lingling#[1]Tang, Jie[2];Chang, Yunli[1];Hang, Dongyun[1];Ji, Jieru*[1]Chen, Guoyu*[1]
  • 语种:
    英文
  • 期刊:
    BIOCHEMICAL PHARMACOLOGY ISSN:0006-2952 2025 年 232 卷 ; FEB
  • 收录:
  • 关键词:
  • 摘要:

    Cyclin G2 (CCNG2), a known inhibitor of cell cycle progression, has been identified as a suppressor for the canonical (3-catenin pathway. This study explores the impact of CCNG2 on (3-catenin activity and malignant characteristics of esophageal squamous cell carcinoma (ESCC) cells, and the mechanism behind CCNG2 dysregulation. In ESCC tissues and cells, CCNG2 was under-expressed and associated with poor clinical outcomes, whereas (3-catenin showed an opposite trend. Inducing CCNG2 overexpression in ESCC cells led to a reduction in (3-catenin levels, which in turn suppressed proliferation, cell cycle progression, migration, invasion, stemness, and tumorigenesis. Additionally, it enhanced the cytotoxicity and proliferation of T cells in co-culture systems. However, these beneficial effects were negated by the Wnt signaling agonist BML-284. Furthermore, PATZ1 was found as a transcription factor promoting CCNG2 transcription. However, the PATZ1 protein in ESCC cells was degraded by SMURF1. Silencing of SMURF1 restored CCNG2 expression and inhibited (3-catenin, thereby suppressing the malignant phenotype of ESCC cells and reducing T cell exhaustion. Yet, these effects were blocked by further silencing of PATZ1. In summary, this research demonstrates that SMURF1 activates (3-catenin signaling by suppressing the PATZ1/CCNG2 axis, thereby promoting the progression of ESCC.

  • 推荐引用方式
    GB/T 7714:
    Chen Lingling,Tang Jie,Chang Yunli, et al. SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription [J].BIOCHEMICAL PHARMACOLOGY,2025,232.
  • APA:
    Chen Lingling,Tang Jie,Chang Yunli,Hang Dongyun,&Chen Guoyu.(2025).SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription .BIOCHEMICAL PHARMACOLOGY,232.
  • MLA:
    Chen Lingling, et al. "SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription" .BIOCHEMICAL PHARMACOLOGY 232(2025).
  • 入库时间:
    1/14/2025 9:23:52 PM
  • 更新时间:
    1/14/2025 9:23:52 PM
浏览次数:10 下载次数:0
浏览次数:10
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部